A Dde-based carboxy linker for solid-phase synthesis

Authors
Chhabra, SR Parekh, H Khan, AN Bycroft, BW Kellam, B
Citation
Sr. Chhabra et al., A Dde-based carboxy linker for solid-phase synthesis, TETRAHEDR L, 42(11), 2001, pp. 2189-2192
Citations number
30
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
11
Year of publication
2001
Pages
2189 - 2192
Database
ISI
SICI code
0040-4039(20010311)42:11<2189:ADCLFS>2.0.ZU;2-Q
Abstract
The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocy clohexylidene)-3-melhylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard a cid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and its utility illustrated by the construction of model peptides, Leu-enkepha lin and Human Angiotensin II. (C) 2001 Elsevier Science Ltd. All rights res erved.