An enzyme-triggered enantio-convergent cascade-reaction

Authors
Mayer, SF Steinreiber, A Orru, RVA Faber, K
Citation
Sf. Mayer et al., An enzyme-triggered enantio-convergent cascade-reaction, TETRAHEDR-A, 12(1), 2001, pp. 41-43
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
1
Year of publication
2001
Pages
41 - 43
Database
ISI
SICI code
0957-4166(20010205)12:1<41:AEEC>2.0.ZU;2-A
Abstract
The biocatalytic hydrolysis of the (+/-)-2,3-disubstituted cis-chloroalkyl epoxides 1a and 2a using resting cells of Rhodococcus sp. did not give the corresponding chloroalkyl vic-diols 1b, and 2b, respectively, but furnished the rearranged products (2R,3R)-1c and (2R,3R)-2c in high e.e. as the sole products via an enzyme-triggered enantio-convergent cascade-reaction. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.