Design and synthesis of useful intermediates for novel lipoxygenase substrates through enzymatic resolution

Authors
Yadav, JS Nanda, S Rao, AB
Citation
Js. Yadav et al., Design and synthesis of useful intermediates for novel lipoxygenase substrates through enzymatic resolution, TETRAHEDR-A, 12(1), 2001, pp. 53-57
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
1
Year of publication
2001
Pages
53 - 57
Database
ISI
SICI code
0957-4166(20010205)12:1<53:DASOUI>2.0.ZU;2-S
Abstract
Unnatural lipoxygenase substrates carrying spacing modifiers with a non-ion ic hydroxy terminus and with methylene (flanked by the cis,cis diene moiety ) pro-(S)-hydrogen can be synthesized from the intermediates la-lc. These i ntermediates are conveniently synthesized via enzymatic resolution with lip ase in organic solvents. (C) 2001 Elsevier Science Ltd. All rights reserved .