The synthesis of L-proline derived tetraazamacrocyclic ligands of C-2 symmetry via intramolecular ester aminolysis

Authors
Achmatowicz, M Jurczak, J
Citation
M. Achmatowicz et J. Jurczak, The synthesis of L-proline derived tetraazamacrocyclic ligands of C-2 symmetry via intramolecular ester aminolysis, TETRAHEDR-A, 12(1), 2001, pp. 111-119
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
1
Year of publication
2001
Pages
111 - 119
Database
ISI
SICI code
0957-4166(20010205)12:1<111:TSOLDT>2.0.ZU;2-8
Abstract
A convenient and efficient synthesis of enantiomerically pure 12-. 14-, and 16-membered tetraazamacrocyclic ligands, able to form complexes with trans ition metal cations, is discussed. Linear alpha,omega -aminoesters, prepare d from L-proline, undergo intramolecular aminolysis to afford the correspon ding macrocyclic amides in good yields. (C) 2001 Elsevier Science Ltd. All rights reserved.