AIDS epidemic at the beginning of the third millennium: time for a new AIDS vaccine strategy

Current expansion of AIDS pandemic significantly accelerates AIDS vaccine r esearch resulting in development and clinical testing of several AIDS vacci ne candidates. At the same time, available experimental and clinical data d emonstrate that current AIDS vaccine strategy is unsuccessful resulting in development of inefficient and harmful vaccines. This overview briefly summ arizes reported results which point out the requirement for moratorium on t he current clinical trials of HIV-1 gp120/160 vaccines and urgent need for development of a new, efficient and safe AIDS vaccine strategy. (C) 2001 El sevier Science Ltd. All rights reserved.