Combined toxicity of Cassia senna and Citrullus colocynthis in rats

Body weight loss, inefficiency of feed utilization, diarrhea, ruffled hair and enterohepatonephrotoxicity were effects on male Wistar rats fed diet co ntaining 10% Cassia senna or 10% Citrullus colocynthis ripe fruits for 6 w. Rats fed a 1:1 mixture (5% + 5%) of fruits from these plants were more adv ersely affected and had deaths than rats fed the individual plants. The cha nges associated with the macrocytic hypochromic anemia and leukopenia were increased serum AST, ALT and ALP activities, increased urea, and decreased total protein, albumin and calcium. Serum bilirubin concentration did not c hange.