Application of genetic semihomology algorithm to theoretical studies on various protein families

Several protein families of different nature were studied for genetic relat ionship, correct alignment; at non-homologous fragments, optimal sequence c onsensus construction, and confirmation of their actual relevance. A compar ison of the genetic semihomology approach with statistical approaches indic ates a high accuracy and cognition significance of the former. This is part icularly pronounced in the study of related proteins that show a low degree of homology. The sequence multiple alignments were verified and corrected with respect to the questionable, non-homologous fragments. The verified al ignments were the basis for consensus sequence formation. The frequency of six-codon amino acids occurrence versus position variability was studied an d their possible role in amino acid mutational exchange at variable positio ns is discussed.