NEUROPROTECTIVE EFFECT OF ACIDIC FIBROBLAST GROWTH-FACTOR ON SEIZURE-ASSOCIATED BRAIN-DAMAGE

Authors
CUEVAS P REVILLA C HERRERAS O LARGO C GIMENEZGALLEGO G
Citation
P. Cuevas et al., NEUROPROTECTIVE EFFECT OF ACIDIC FIBROBLAST GROWTH-FACTOR ON SEIZURE-ASSOCIATED BRAIN-DAMAGE, Neurological research, 16(5), 1994, pp. 365-369
Citations number
30
Categorie Soggetti
Neurosciences
Journal title
Neurological research → ACNP
ISSN journal
01616412
Volume
16
Issue
5
Year of publication
1994
Pages
365 - 369
Database
ISI
SICI code
0161-6412(1994)16:5<365:NEOAFG>2.0.ZU;2-E
Abstract
The neuroprotective effect of acidic fibroblast growth factor (aFCF) h as been analysed in a rat model of seizures-associated brain damage. W e report that after treatment with a convulsivant dose of Kainic acid, systemically administered aFCF prevents neuronal degeneration in spec ific brain areas, mainly in the hyppocampal formation. Our findings ex tend the potential pharmacological use of fibroblast growth factors an d afford new data to understand the neurophysiology of these proteins.