Treatment of focal in-stent restenosis with balloon angioplasty alone versus stenting: Short- and long-term results

Background Although both percutaneous transluminal coronary angioplasty (PT CA) and additional stenting can be used For the treatment for focal in-sten t restenosis (ISR), no large-scale comparative data on the clinical outcome s after these interventional procedures have been reported. Methods in the current study we compared the in-hospital and long-term clin ical results of PTCA alone (n = 266 patients, n = 364 lesions) versus stent ing (n = 135 patients, n = 161 lesions) for the treatment of focal ISR, def ined as a lesion length less than or equal to 10 mm. Results There were significantly more diabetic patients in the PTCA group t han in the stent group (36% vs 26%, P = .04), but other baseline characteri stics were similar. Lesion length and preprocedure minimal lumen diameter ( MLD) were also similar in the two groups, but the stent group had a larger reference vessel diameter (3.40 +/- 0.73 mm vs 2.99 +/- 0.68 mm, P < .001). Stenting achieved a larger postprocedure MLD than PTCA did (2.95 +/- 0.95 mm vs 2.23 +/- 0.60 mm, P < .001) and a smaller residual diameter stenosis (11% + 15% vs 23% + 16%, P = .04). Angiographic success was achieved in all cases. The rate of death/Q-wave infarction of urgent revascularization was higher with PTCA than with stent (5.6% vs 0.7%, P = .02). Postprocedure cr eatine kinase myocardial band enzyme elevation >5 times normal was more fre quent with stent (18.5% vs 9.7%, P = .05). At 1 year the two interventional strategies had similar cumulative mortality (4.6% PTCA vs 5.1% stent, P no t significant) and target lesion revascularization rate (24.6% PTCA vs 26.5 % stent, P not significant). By multivariate analysis, the sole predictor o f target lesion revascularization was diabetes (odds ratio 2.4, 95% confide nce intervals 1.2-4.7, P = .01). Conclusion Repeat stenting for the treatment of focal ISR had a higher post procedure creatine kinase myocardial band elevation rate and similar long-t erm clinical results compared with PTCA alone.