Primary endometrial T-cell lymphoma - A case report

Primary lymphomas of the female genital tract are rare. Most involve the ce rvix rather than the uterine corpus. All of those previously reported have been B-cell lymphomas, with the exception of 1 case report of an endometria l T-cell lymphoma in a Japanese woman. We report the case of a white woman from the United States with a diffuse large cell lymphoma of the endometriu m, characterized as a peripheral T-cell type on the basis of immunophenotyp ic and molecular probe studies. Staging evaluation revealed tumor limited t o the endometrium (stage IE). The patient underwent a total abdominal hyste rectomy, bilateral salpingo-oophorectomy and lymph node dissection mid rece ived 6 cycles of combination chemotherapy, after which she remained free of disease at last follow-up of 36 months. Unusual features of this lymphoma case are discussed, with emphasis on differential diagnosis and speculation on histogenesis. This case illustrates that while most peripheral T-cell l ymphomas are widely disseminated at presentation those limited to a single extranodal site may have a favorable outcome akin to that associated with h igh-grade extranodal B-cell lymphomas of early stage.