Rapid publication - Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22, and 11q23-24 in south African Afrikaners

Utilizing DNA samples from 91 Afrikaner nuclear families with one or more a ffected children, five genomic regions on chromosomes 2p, 8q, 11q, 20q, and 21q that gave evidence for association with GTS in previous case-control a ssociation studies were investigated for linkage and association with GTS, Highly polymorphic markers with mean heterozygosity of 0.77 were typed and resulting genotypes evaluated using single marker transmission disequilibri um (TDT), single marker haplotype relative risk (HRR), and multi-marker "ex tended" TDT and HRR methods. Single marker TDT analysis showed evidence for linkage or association, with p-values near 0.05, for markers D2S139, GATA2 8F12, and D11S1377 on chromosomes 2p11, 8q22 and 11q23-24, respectively. Ex tended, two-locus TDT and HRR analysis provided further evidence for Linkag e or association on chromosome 2 with p-values of 0.007 and 0.025, and chro mosome 8 with p-values of 0.059 and 0.013, respectively. These results prov ide important additional evidence for the location of GTS susceptibility lo ci. (C) 2001 Wiley-Liss, Inc.