H. Hori et al., Association analysis between two functional dopamine D2 receptor gene polymorphisms and schizophrenia, AM J MED G, 105(2), 2001, pp. 176-178
The dopamine D2 receptor (DRD2) gene has been listed as one of the candidat
e genes for susceptibility to schizophrenia. To date, a significant associa
tion between schizophrenia and two functional DRD2 gene polymorphisms, Ser3
11Cys and -141C Ins/Del, in Japanese samples, has been reported by Arinami
ct al, [1994: Lancet 343:703-704; 1997: Hum Mol Genet 6:577-582], In the pr
esent study, we replicated the findings of Arinami ct al, [1994: Lancet 343
:703-704; 1997: Hum Mol Genet 6:577-582] in the same ethnic groups (Japanes
e samples) with the same polymorphisms (Ser311Cys and -141C Ins/Del), We ge
notyped these two polymorphisms for 241 patients and for 201 controls. Neit
her polymorphism was associated with schizophrenia. Moreover, in a haplotyp
e analysis of the present sample, combined pairs of two polymorphisms provi
ded no evidence for the association of either haplotype with schizophrenia.
Our findings indicate that an association between the two functional DRD2
gene polymorphisms, Ser311Cys and -141C Ins/ Del, and schizophrenia is unli
kely. (C) 2001 Wiley-Liss, Inc.