Atypical presentation of Amniotic Band Sequence

Amniotic Band Sequence (ABS) is a disruption sequence that results in a var iable group of abnormalities secondary to the disruption process and subseq uent deformations. The incidence of ABS ranges from 1:1,200 to 1:15,000 liv e-born, and is even higher in still-born [Froster and Baird, 1993: Am J Med Genet 46:497-500]. The pathophysiology of ABS remains controversial, but a close look to critical periods of embryogenesis and/or organogenesis has h elped in understanding pathogenetic mechanisms leading to the ABS disruptio n. The abnormalities are typically limited to external structures; however, associated internal malformations as seen in the case reported here may oc cur [Hunter and Carpenter, 1986: Am J Med Genet 24:691-700], The prognosis depends on the severity of the abnormalities and the involvement of interna l organs [Froster and Baird; 1993: Am J Med Genet 46:497-500; Levy, 1998: F ed Rev 19:249]. (C) 2001 Wiley-Liss, Inc.