Paraneoplastic acquired ichtyosis revealing malignant lymphoma.

Background. Paraneoplastic ichthyosis is a rare affection generally associa ted with malignant hemopathy. Case report. A 61 year-old man was seen with a generalized ichthyosis assoc iated with a palmoplantar hyperkeratosis developed over the last 2 years, a nd an axillary lymph node. Histology of the lymph node revealed a large cel l anaplastic lymphoma. Both ichthyosis and palmoplantar keratosis totally d isappeared three weeks after adenectomy, without any other treatment. Discussion. This rapid and complete regression of ichthyosis, after the sol e ablation of the involved lymph node confirmed the paraneoplastic nature o f the disorders of the keratinization (ichtyosis, palmoplantar keratodermia ). The review of the literature showed only one case characterized by a rap id disappearance of ichthyosis after surgical treatment of the malignant ly mphoma.