Gastrostomy tube placement in nonadherent HIV-infected children

OBJECTIVE: TO determine the benefits of gastrostomy tube (G-tube) placement in HIV-infected children receiving highly active antiretroviral therapy (H AART). METHODS: Children who had a G-tube placed due to medication adminsitration difficulties were followed to determine changes in medication adherence and changes in laboratory parameters. Medication adherence and laboratory para meters were reviewed for three months prior to G-tube placement and then we re followed for six months after G-tube placement. Viral RNA and CD4+ count s were assessed between the two time periods. Medication adherence was foll owed by review of pharmacy refill records and pill counts. Parents were sur veyed about their opinion regarding the G-tube placement and medication adm inistration in their children. RESULTS: Six children had G-tubes placed due to medication administration d ifficulties. The G-tube was tolerated in all six cases, although one child developed a staphylococcal infection 13 months after G-tube placement. Befo re G-tube placement, the medication adherence to HAART averaged 47% +/- 20% SD, with a range of 15-90%. After G-tube placement, medication adherence i mproved to 90-100%. All parents were satisfied with the G-tube and all repo rted shorter medication administration times and fewer behavioral problems. Five of six patients had at least a 2-log(10) decrease in viral load, and CD4+ percentages improved by an average of 6.4%. CONCLUSIONS: G-tubes were well tolerated by HIV-infected children. Although G-tube placement is not needed in most children with HIV, it may provide a n option for parents and children where administration of antiretroviral me dication poses extreme difficulty and all other avenues have been exhausted .