Piriformis syndrome (PS) is an unusual cause of sciatica that, because of t
he lack of strict diagnostic criteria, remains a controversial clinical ent
ity. The diagnosis of PS is still primarily clinical because no diagnostic
tests hale proven to be definitive. We report the case of a 30-year-old wom
an, affected by a severe scoliosis, who developed a persistent buttock pain
resembling that of PS. The clinical suspicion was confirmed by magnetic re
sonance imaging (MRI) of the pelvis. which showed an enlargement of the lef
t piriformis muscle with an anterior is placement of the sciatic nerve. The
role of MRI in the diagnosis, clinical definition, and therapeutic approac
h to PS is discussed.