Matrix metalloproteinases of normal human tissues

This review considers biochemical properties of the family of matrix metall oproteinases (MMPs) of normal human tissues and the involvement of these en zymes in morphogenesis. Four main MMP subfamilies are characterized, and a group of other MMPs is described. Data on mechanisms of activation and inhi bition of MMPs in certain tissues during various physiological processes (e mbryogenesis, angiogenesis, tissue growth and involution) are considered. i nformation about tissue inhibitors of MMP is presented, and the ability of these inhibitors to regulate the activity of MMPs is analyzed.