Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element

Authors
Dailly, YP Zhou, YH Linkhart, TA Baylink, DJ Strong, DD
Citation
Yp. Dailly et al., Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element, BBA-GENE ST, 1518(1-2), 2001, pp. 145-151
Citations number
40
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1518
Issue
1-2
Year of publication
2001
Pages
145 - 151
Database
ISI
SICI code
0167-4781(20010319)1518:1-2<145:SACOTH>2.0.ZU;2-N
Abstract
The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5'-flanking region was sequenced and found to have promoter activity in hum an osteoblasts. The sequence contains four clustered transcription start si tes and three retinoic acid response elements (RAREs) with widely spaced ha lf-sites. Only the proximal DR15 RARE was functional. Retinoids increased I GFBP-6 promoter activity up to 3-fold. (C) 2001 Published by Elsevier Scien ce B.V.