Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating ratliver

Authors
Liu, ZW Zhao, MJ Yokoyama, KK Li, TP
Citation
Zw. Liu et al., Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating ratliver, BBA-GENE ST, 1518(1-2), 2001, pp. 183-189
Citations number
20
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1518
Issue
1-2
Year of publication
2001
Pages
183 - 189
Database
ISI
SICI code
0167-4781(20010319)1518:1-2<183:MCOACF>2.0.ZU;2-T
Abstract
il-TMP (also known as TM4SF4) is a human tetraspanin that is expressed in h uman intestine and liver. We have cloned a novel cDNA for a rat gene with s equence similar to that of a cDNA for human il-TMP. The cDNA encoded a prot ein of 202 amino acids, designated rat TM4SF4. The corresponding transcript was detected in rat liver and testis. The expression of rat TM4SF4 was enh anced in regenerating liver after two-thirds partial hepatectomy. It was su pposed that rat TM4SF4 might play a role in cell proliferation and in liver regeneration. (C) 2001 Elsevier Science B.V. All rights reserved.