Inhibitory effects of sophoraflavanones B and H in Sophora mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate in vitro

We present the results of an in vitro investigation of the inhibitory effec ts of sophoraflavanones B and H isolated from Sophora mooracroftiana Beth e x Baker on copper-induced protein oxidative modification. They inhibited co pper-induced protein oxidative modification. Their effects were stronger th an those of naringenin as a related flavanone, and of mannitol as a hydroxy l radical scavenger. The results suggest that these natural products may be of use in cases where oxidative stress is present.