Chiral derivatization reagents for drug enantioseparation by high-performance liquid chromatography based upon pre-column derivatization and formation of diastereomers: enantioselectivity and related structure
Xx. Sun et al., Chiral derivatization reagents for drug enantioseparation by high-performance liquid chromatography based upon pre-column derivatization and formation of diastereomers: enantioselectivity and related structure, BIOMED CHRO, 15(2), 2001, pp. 116-132
Structures and related enantioselectivities of the respective chiral deriva
tization reagents (CDRs) for drag enantioseparation by high-performance chr
omatography based upon pre-column derivatization and diastereomeric formati
on are reviewed. The elution order of diastereomers caused reaction of some
CDRs with enantiomeric amino acids and carboxylic acids. The development o
f new CDRs available for indirect HPLC methods is also discussed. Copyright
. (C) 2001 John Wiley & Sons, Ltd.