New artificial siderophores based on a monosaccharide scaffold

Authors
Heggemann, S Schnabelrauch, M Klemm, D Mollmann, U Reissbrodt, R Heinisch, L
Citation
S. Heggemann et al., New artificial siderophores based on a monosaccharide scaffold, BIOMETALS, 14(1), 2001, pp. 1-11
Citations number
26
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOMETALS
ISSN journal
09660844 → ACNP
Volume
14
Issue
1
Year of publication
2001
Pages
1 - 11
Database
ISI
SICI code
0966-0844(200103)14:1<1:NASBOA>2.0.ZU;2-L
Abstract
New artificial catecholate siderophores with methyl alpha -D-glucopyranosid e as scaffold were synthesized. The dihydroxy- or di(acetoxy)benzoyl moieti es were attached either directly or via aminopropyl spacer groups, to the c arbohydrate scaffold. The siderophore activity of the prepared siderophore analogs was examined by a growth promotion assay using various Gram-negativ e bacteria and mycobacteria and by the CAS-assay.