Discovery of a novel lead structure for anti-malarials

Authors
Wiesner, J Wissner, P Dahse, HM Jomaa, H Schlitzer, M
Citation
J. Wiesner et al., Discovery of a novel lead structure for anti-malarials, BIO MED CH, 9(3), 2001, pp. 785-792
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
3
Year of publication
2001
Pages
785 - 792
Database
ISI
SICI code
0968-0896(200103)9:3<785:DOANLS>2.0.ZU;2-O
Abstract
From a library of 61 compounds available from former studies 2,5-bis-acylam inobenzophenone 7p was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum st rain Dd2. Some structural modifications of this initial lead demonstrated t he potential for further improvement of the anti-plasmodial activity of thi s novel class of anti-malarials. (C) 2001 Elsevier Science Ltd. All rights reserved.