Biotransformation of a 4(20),11(12)-taxadiene derivative

Authors
Sun, DA Sauriol, F Mamer, O Zamir, LO
Citation
Da. Sun et al., Biotransformation of a 4(20),11(12)-taxadiene derivative, BIO MED CH, 9(3), 2001, pp. 793-800
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
3
Year of publication
2001
Pages
793 - 800
Database
ISI
SICI code
0968-0896(200103)9:3<793:BOA4D>2.0.ZU;2-1
Abstract
A 4(20),11(12)-taxadiene derivative was converted to hydroxylated derivativ es by Cunninghamella elegans AS3.2033 and Cunninghamella elegans var chibae nsis ATCC 20230. Both microorganisms led to C-1 hydroxylations and conversi on to a C-15-hydroxylated abeo-taxane. Additional products from the two fun gi differed: a C-14 oxidation and a trans-cis isomerization of the cinnamoy l for one and an unprecedented hydroxylation at C-17 for the other. (C) 200 1 Elsevier Science Ltd. All rights reserved.