M. Ozcan et al., Recombinant human granulocyte colony-stimulating factor (rh-G-CSF) may accelerate hematopoietic recovery after HLA-identical sibling allogeneic peripheral blood stem cell transplantation, BONE MAR TR, 27(5), 2001, pp. 499-505
Citations number
37
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
We studied the effects of recombinant human granulocyte colony-stimulating
factor (G-CSF) on hematopoietic recovery and clinical outcome in patients u
ndergoing allogeneic peripheral blood stem cell (PBSC) transplantation. Fif
ty-six patients with hematological malignancies who underwent allogeneic PB
SC transplantation between 1995 and 1998 were entered into this study. Twen
ty-eight patients who received daily G-CSF from day +1 after allogeneic PBS
C transplantation until the absolute neutrophil count (ANC) reached >0.5 x
10(9)/l for 3 consecutive days were compared with 28 patients (control grou
p) who did not receive G-CSF in a non-randomized manner. The study group an
d the control group were comparable with respect to baseline patient and tr
ansplantation characteristics. Median times to ANC of >0.5 x 10(9)/l and 1
x 10(9)/l with or without G-CSF were 12 days (range 8-21), 13 days (10-32)
(P = 0.04) and 13 days (9-21), 15 days (11-44) (P = 0.02), respectively, Me
dian times to reach a platelet count of >20 x 10(9)/l with and without G-CS
F were 11 days (0-20) and 13 days (9-26), respectively (P = 0.03), The inci
dence of febrile episodes was significantly lower with G-CSF, 75% vs 100% (
P = 0.008), Patients receiving G-CSF had less grade III-IV mucositis than t
hose who did not receive G-CSF (P = 0.01), There was also no increase in th
e incidence and severity of acute GVHD in patients using G-CSF (P = 0.22),
Although the number of relapsing patients was greater in the G-CSF group (s
even vs three patients), this was not statistically significant (P = 0.24),
Disease-free and overall survival rates did not differ between the two gro
ups (P = 0.58 and 0.53, respectively). The administration of G-CSF after al
logeneic PBSC transplantation provided faster neutrophil and platelet engra
ftment associated with less severe mucositis and less febrile episodes.