Jl. Byrne et al., Successful engraftment of a second transplant using non-myeloablative conditioning as treatment for graft failure following unrelated donor BMT, BONE MAR TR, 27(5), 2001, pp. 547-549
Citations number
15
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
A 32-year-old man with CML in second chronic phase developed primary graft
failure following matched unrelated donor transplantation using cryopreserv
ed marrow cells. He was successfully regrafted within 60 days from a second
fully matched donor using a non-myeloablative conditioning regimen, with m
inimal toxicity. He remains in complete haematological, cytogenetic and mol
ecular remission 2 years after second transplant, We believe that reduced i
ntensity or 'mini-transplants' may be preferable for patients requiring sec
ond allografts which are usually associated with a high transplant-related
mortality.