Spatio-temporal current density reconstruction (stCDR) from EEG/MEG-data

Among the different approaches to the bioelectromagnetic inverse problem, t he current-density reconstruction methods (CDR) provide the most general so lutions. Since the inverse problem does not have a unique solution, model a ssumptions have to be taken into account. Multi-channel measurements contai n not only spatial, but also temporal information about the sources, so a n aturally extension to existing methods leads to spatio-temporal model const raints. Spatio-temporal CDR's (stCDR) have been tested in simplified volume conductor models, assuming different spatial model constraints and a smoot h temporal activation model. Comparison to existing spatial model constrain ts showed a significant improvement of spatial and temporal resolution of t he reconstructed sources for the spatio-temporal models especial in noisy d ata.