Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers

Background Activated protein C (APC) resistance is the most frequently diag nosed heritable thrombophilic defect predisposing to thrombosis, Objectives To determine the prevalence of APC resistance due to factor V Le iden mutation in patients with leg ulcers. Methods Within a 2-year-period 100 consecutive patients with leg ulcers wer e examined for factor V Leiden mutation. Results APC resistance due to factor V Leiden mutation was detected in 19 o f 53 patients (36%) with post-thrombotic leg ulcers and in three of 47 pati ents (6%) with ulcers caused by primary varicosis. In a healthy control gro up APC resistance due to factor V Leiden mutation was found in five of 96 ( 5%) volunteers. Conclusions In view of this high prevalence of APC resistance of 36%, which has never previously been reported, patients with post-thrombotic. leg ulc ers should be investigated for APC resistance.