Growth hormone secretion and sensitivity in men with idiopathic osteoporosis

Previous studies have suggested that insulin-like growth factor-I (IGF-I) a nd its binding proteins (IGFBPs) have a pathogenetic role in idiopathic ost eoporosis. To investigate this question further we compared 20 men with idi opathic osteoporosis with 12 healthy, age-matched men regarding growth horm one (GH) secretion and sensitivity. GH samples were drawn every 30 minutes for 24 hours From 12 of the patients and all controls, and cumulated GH sec retion (24hGH) was derived. Peak GH secretion (peakGH) was provoked by an i nsulin tolerance test. There were no differences between the groups in seru m IGF-I (162 +/- 30 vs 163 +/- 47 mug/liter, mean +/- SD), IGFBP-3 (2474 +/ - 263 vs 2568 +/- 197 mug/liter), 24hGH (1.34 +/- 1.26 vs 0.79 +/- 0.43 U), or peakGH (53.0 +/- 21.5 vs 44.1 +/- 19.8 mU/liter). Patients and controls were given GH (2.4 U/day) for 1 week. Serum levels of markers for bone tur nover increased significantly in both groups, with no difference in respons e to GH between the groups. The increase in urinary bone resorption markers was only significant in the controls. In the patients, but not in the cont rols, there were significant positive correlations between indices for GH s ecretion and markers for bone turnover at baseline and significant negative correlations with relative changes in bone markers during GH treatment. In this study no difference in GH secretion was found between men with idiopa thic osteoporosis and controls, but the findings suggest that the GH/IGF-I axis could play a regulatory role in bone metabolism in men with this condi tion.