Studies on the constituents of Broussonetia species VIII. Four new pyrrolidine alkaloids, broussonetines R, S, T, and V and a new pyrroline alkaloid,broussonetine U, from Broussonetia kazinoki Sieb.

Four new pyrrolidine alkaloids, broussonetines R, S, T, and V and a new pyr roline alkaloid, broussonetine U were isolated from the branches of Brousso netia kazinoki SIEB. (Moraceae) in low yield. Broussonetines R, S and T wer e formulated as (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-{(1R)-1-hydro xy-3-[6-(4-hydroxybutyl)-cyclohexy-2-on-1(6)-enyl]propyl} pyrrolidine (I), (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5- [(1R,10S)-1,10,13-trihydroxy tridecyl] pyrrolidine (2), (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[( IR,5S)-1,5, 13-tri-hydroxy-10-oxo-tridecyl] pyrrolidine (3). And broussonet ines U and V were proposed to be (2S,3S,4S)-2-hydroxymethyl-3, 4-dihydroxy- 5-(9-oxo-13-hydroxytridecyl)-5-pyrroline (4), (2R,3R,4R,5R)-2-hydroxymethyl -3,4-dihydroxy-5-[(E)-9-oxo-13-hydroxy-3-tridecenyl] pyrrolidine (5), respe ctively, by spectroscopic and chemical methods.