The first example for cycloenantiomeric hexahomooxacalix[3] arenes

Authors
Tsubaki, K Otsubo, T Kinoshita, T Kawada, M Fuji, K
Citation
K. Tsubaki et al., The first example for cycloenantiomeric hexahomooxacalix[3] arenes, CHEM PHARM, 49(4), 2001, pp. 507-509
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
4
Year of publication
2001
Pages
507 - 509
Database
ISI
SICI code
0009-2363(200104)49:4<507:TFEFCH>2.0.ZU;2-H
Abstract
Cycloenantiomeric hexahomooxacalix[3]arenes with different substituents on the three upper rims were synthesized for the first time by fixing their co nformation into a cone, A cycloenantiomeric hexahomooxacalix[3]arene 6 was resolved into both enantiomeric forms and chiroptically characterized. Prel iminary H-1-NMR studies indicated that the optically resolved cycloenantiom er 6 could discriminate the enantiomers of hydrochloride of phenylalanine e thyl ester.