A stable DNA tetraloop and its structural tolerance for modification

Authors
Kawakami, J Yoneyama, M Miyoshi, D Sugimoto, N
Citation
J. Kawakami et al., A stable DNA tetraloop and its structural tolerance for modification, CHEM LETT, (3), 2001, pp. 258-259
Citations number
10
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
3
Year of publication
2001
Pages
258 - 259
Database
ISI
SICI code
0366-7022(20010305):3<258:ASDTAI>2.0.ZU;2-L
Abstract
Structural features of a stable hairpin DNA with a tetraloop, dAGGC(TTCG)GC CT (CORE), and its six abasic mutants were investigated by the melting beha vior of the UV absorption and circular dichroism spectra. The CORE and an a basic mutant at the second position of the loop exhibit considerable thermo dynamic stability and have similar structural features suggesting the same folding with an identical base orientation of the two hairpin DNAs except f or the second base in the loop.