Distribution of Chlamydia pneumoniae in the human arterial system and its relation to the local amount of atherosclerosis within the individual

Citation
A. Vink et al., Distribution of Chlamydia pneumoniae in the human arterial system and its relation to the local amount of atherosclerosis within the individual, CIRCULATION, 103(12), 2001, pp. 1613-1617
Citations number
22
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CIRCULATION
ISSN journal
00097322 → ACNP
Volume
103
Issue
12
Year of publication
2001
Pages
1613 - 1617
Database
ISI
SICI code
0009-7322(20010327)103:12<1613:DOCPIT>2.0.ZU;2-2
Abstract
Background-Chlamydia pneumoniae has been suggested to play a role in the or igin of atherosclerosis. We studied the prevalence of C pneumoniae at multi ple locations in the arterial system within the same individual. Studying t he association between atherosclerosis and C pneumoniae within the individu al excludes confounding by interindividual variability. Methods and Results-Postmortem, the presence in the intima/plaque and media of C pneumoniae membrane protein was determined by use of a C pneumoniae-s pecific monoclonal antibody. In 24 individuals, 33 arterial locations were studied (n = 738 segments). Area stenosis was determined in adjacent cross sections. In all individuals, immunostaining of C pneumoniae was observed i n greater than or equal to1 artery. The highest prevalences were observed i n the abdominal aorta (67%), internal and common iliac arteries (41%), and coronary arteries (33%). The lowest prevalences were observed in the radial (0%) and cerebral (2%) arteries. Within the individual, area stenosis was larger in cross sections with immunoreactivity compared with cross sections without immunoreactivity (31.0 +/- 11.9% versus 14.3 +/-6.1%, respectively ; P<0.001). In the individual, immunoreactivity was observed in 15<plus/min us>10% of the arteries (range, 3% to 45%). Between individuals, the percent age of arteries with immunoreactivity to C pneumoniae was associated with t he average area stenosis throughout the arterial system (r(2)=0.56, P<0.001 ). Conclusions-C pneumonine was mostly observed at locations that are related to clinically relevant features. Within the individual, the distribution of C pneumoniae is associated with the distribution of atherosclerosis. The r ole of the microorganism in atherosclerotic disease remains to be elucidate d.