A. Vink et al., Distribution of Chlamydia pneumoniae in the human arterial system and its relation to the local amount of atherosclerosis within the individual, CIRCULATION, 103(12), 2001, pp. 1613-1617
Citations number
22
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-Chlamydia pneumoniae has been suggested to play a role in the or
igin of atherosclerosis. We studied the prevalence of C pneumoniae at multi
ple locations in the arterial system within the same individual. Studying t
he association between atherosclerosis and C pneumoniae within the individu
al excludes confounding by interindividual variability.
Methods and Results-Postmortem, the presence in the intima/plaque and media
of C pneumoniae membrane protein was determined by use of a C pneumoniae-s
pecific monoclonal antibody. In 24 individuals, 33 arterial locations were
studied (n = 738 segments). Area stenosis was determined in adjacent cross
sections. In all individuals, immunostaining of C pneumoniae was observed i
n greater than or equal to1 artery. The highest prevalences were observed i
n the abdominal aorta (67%), internal and common iliac arteries (41%), and
coronary arteries (33%). The lowest prevalences were observed in the radial
(0%) and cerebral (2%) arteries. Within the individual, area stenosis was
larger in cross sections with immunoreactivity compared with cross sections
without immunoreactivity (31.0 +/- 11.9% versus 14.3 +/-6.1%, respectively
; P<0.001). In the individual, immunoreactivity was observed in 15<plus/min
us>10% of the arteries (range, 3% to 45%). Between individuals, the percent
age of arteries with immunoreactivity to C pneumoniae was associated with t
he average area stenosis throughout the arterial system (r(2)=0.56, P<0.001
).
Conclusions-C pneumonine was mostly observed at locations that are related
to clinically relevant features. Within the individual, the distribution of
C pneumoniae is associated with the distribution of atherosclerosis. The r
ole of the microorganism in atherosclerotic disease remains to be elucidate
d.