Higher-order structure of chromatin and chromosomes

Authors
Woodcock, CL Dimitrov, S
Citation
Cl. Woodcock et S. Dimitrov, Higher-order structure of chromatin and chromosomes, CUR OP GEN, 11(2), 2001, pp. 130-135
Citations number
75
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
130 - 135
Database
ISI
SICI code
0959-437X(200104)11:2<130:HSOCAC>2.0.ZU;2-U
Abstract
The linear array of nucleosomes that comprises the primary structure of chr omatin is folded and condensed to varying degrees in nuclei and chromosomes forming 'higher order structures'. We discuss the recent findings from nov el experimental approaches that have yielded significant new information on the different hierarchical levels of chromatin folding and their functiona l significance.