Mechanisms for ATP-dependend chromatin remodelling

During the past year, major advances have been made towards understanding t he function of ATP-dependent chromatin-remodelling activities both in vitro and in vivo. These suggest that ATP-dependent chromatin-remodelling activi ties are capable of both altering the structure of individual nucleosomes a nd acting in concert with other forms of chromatin-modifying enzymes, to re gulate the formation and decondensation of chromatin fibres.