Histone acetyltransferases: function, structure, and catalysis

Authors
Marmorstein, R Roth, SY
Citation
R. Marmorstein et Sy. Roth, Histone acetyltransferases: function, structure, and catalysis, CUR OP GEN, 11(2), 2001, pp. 155-161
Citations number
43
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
155 - 161
Database
ISI
SICI code
0959-437X(200104)11:2<155:HAFSAC>2.0.ZU;2-Y
Abstract
Histone acetyltransferases (HATs) directly link chromatin modification to g ene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk betw een acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, furthe r highlighting the importance of these enzymes to normal cell growth and di fferentiation.