Lymphatic filariasis is recognized as one of the world's most disabling dis
eases. Adult lymphatic filarial nematodes live for several years; they infe
st the lymphatic and blood systems, and are transmitted via mosquito vector
s. Acute and chronic disease can develop, manifesting as acute inflammation
, hydrocoele, lymphoedema and elephantiasis. The development of a global pr
ogramme for the elimination of lymphatic filariasis (focusing on disease ca
used by Wuchereria bancrofti) followed a resolution by the World Health Ass
embly in 1997 that endemic countries should develop programmes to eliminate
lymphatic filariasis as a public health problem. This developed from an ea
rlier recommendation by the international Task Force for Disease Eradicatio
n in 1993 that lymphatic filariasis was one of six diseases that could, in
theory, be eradicated. Herein we review the current status and future prosp
ects of the Global Lymphatic Filariasis Programme, which was launched in 20
00. Curr Opin infect Dis 14:156-159. (C) 2001 Lippincott Williams & Wilkins
.