LIPOSOMAL ANISOTROPY - A SIGNAL FOR LIPID-DRUG INTERACTION AT THE INTERFACE

Using liposomal membranes of different lipids like egg lecithin, sphin gomyelin and dipalmitoyl phosphatidylcholine, we have studied the effe ct of the hydrophilic drugs chloroquine sulphate, nicotinic acid etc. on the membrane anisotropy; which is an index of the membrane microvis cosity. The observed effect is presumably through the charge-charge in teraction between tile lipid head group and the hydrophilic drugs at t he lipid water interface.