Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)

Magnetic resonance imaging (MRI) is a technique commonly used to detect neu ral abnormalities in routine clinical practice. It is perhaps less well kno wn that the technique can be adapted to measure various anatomical and phys iological features of small laboratory rodents. This review focuses on the potential of the MRI technique to image the brain of (transgenic) mouse mod els for neurological diseases, and aims to introduce these exciting new tec hnological developments to the non-specialist reader.