PAX6 CONTROLS PROGENITOR-CELL IDENTITY AND NEURONAL FATE IN RESPONSE TO GRADED SHH SIGNALING

Authors
ERICSON J RASHBASS P SCHEDL A BRENNERMORTON S KAWAKAMI A VANHEYNINGEN V JESSELL TM BRISCOE J
Citation
J. Ericson et al., PAX6 CONTROLS PROGENITOR-CELL IDENTITY AND NEURONAL FATE IN RESPONSE TO GRADED SHH SIGNALING, Cell, 90(1), 1997, pp. 169-180
Citations number
51
Categorie Soggetti
Biology,"Cell Biology
Journal title
Cell → ACNP
ISSN journal
00928674
Volume
90
Issue
1
Year of publication
1997
Pages
169 - 180
Database
ISI
SICI code
0092-8674(1997)90:1<169:PCPIAN>2.0.ZU;2-W
Abstract
Distinct classes of motor neurons and ventral interneurons are generat ed by the graded signaling activity of Sonic hedgehog (Shh). Shh contr ols neuronal fate by establishing different progenitor cell population s in the ventral neural tube that are defined by the expression of Pax 6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell popula tions and controls the identity of motor neurons and ventral interneur ons, mediating graded Shh signaling in the ventral spinal cord and hin dbrain.