Asymmetric synthesis of the C(33)-C(37) fragment of amphotericin B

We have devised an expeditious. efficient, asymmetric synthesis of the C(33 )-C(37) fragment of amphotericin B that proceeds in 14 steps and 16% overal l yield from tiglic aldehyde ((E)-2-methylbut-2-enal) with complete stereoc ontrol. The route described herein relies on the application of recently de veloped methods in catalytic asymmetric synthesis for stereocontrol through enantio- and diastereoselective functionalization of a substituted sorbate derivative.