Application of phthalimidine synthesis with use of 1,2,3-1H-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries. 2. Effective synthesisof phthalimidines possessing bulky group at 2-position

Authors
Takahasi, I Kawakami, T Kimino, M Hirano, E Kamimura, S Tamura, T Kitajima, H Hatanaka, M Uchida, H Nomura, A Tanaka, M
Citation
I. Takahasi et al., Application of phthalimidine synthesis with use of 1,2,3-1H-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries. 2. Effective synthesisof phthalimidines possessing bulky group at 2-position, HETEROCYCLE, 54(2), 2001, pp. 635
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
54
Issue
2
Year of publication
2001
Database
ISI
SICI code
0385-5414(20010201)54:2<635:AOPSWU>2.0.ZU;2-9
Abstract
Potentially bioactive phthalimidines are prepared in fair to good isolated yields by the 1:1 condensation reaction of o-phthalaldehyde with a variety of sterically-hindered primary alkyl amines in the presence of 1,2,3-1 H-be nzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries.