Haterumaimides A-E, five new dichlorolissoclimide-type diterpenoids from an ascidian, Lissoclinum sp.

Authors
Uddin, J Kokubo, S Suenaga, K Ueda, K Uemura, D
Citation
J. Uddin et al., Haterumaimides A-E, five new dichlorolissoclimide-type diterpenoids from an ascidian, Lissoclinum sp., HETEROCYCLE, 54(2), 2001, pp. 1039
Citations number
5
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
54
Issue
2
Year of publication
2001
Database
ISI
SICI code
0385-5414(20010201)54:2<1039:HAFNDD>2.0.ZU;2-N
Abstract
Five new dichlorolissoclimide-type diterpenoids, haterumaimides A-E, were i solated from an ascidian, Lissoclinum sp., and the absolute stereostructure s of haterumaimides A-D and the relative stereostructure of haterumaimide E were determined by spectroscopic and chemical analyses. Haterumaimides A-E inhibited the first cleavage of fertilized sea urchin eggs and exhibited c ytotoxicity against P388 cells.