Impaired glucose tolerance without hypertriglyceridemia does not enhance postprandial lipemia

Postprandial lipemia has been thought to be one of risk factors for coronar y heart disease, and enhances in potential patients for atherosclerotic dis ease. Patients with impaired glucose tolerance (IGT) often show hypertrigly ceride, which is caused by enhanced portprandial lipemia. Therefore, postpr andial lipemia in patients with IGT and without hypertriglyceridemia has no t been cleared. We have examined the levels of plasma triglyceride and chyl omicron remnants after a high fat meal load (1250 kcal, 40% fat and 420 mg cholesterol) in 13 normotriglyceridemic subjects with IGT and 10 controls w ith normal glucose tolerance (NGT). Chylomicron remnants were evaluated as remnant-like particles (RLP) that were not bound to an immunoaffinity gel m ixture containing apo A-I and apo B-100 monoclonal antibody. RLP cholestero l levels 4 hours after the fat load were significantly lower in IGT subject s than in NGT subjects. Increase of RLP cholesterol after the fat meal load only significantly correlated with increase of insulin during the first 30 min after a 75 g oral glucose tolerance test, but not fasting lipid, insul inogenic index and HOMA-R (homeostasis model) in all subjects. These result s suggest that postprandial response does not enhance in IGT subjects, and may associate with early-phase insulin secretion and without insulin resist ance in normotriglyceridemic men with IGT or NGT.