Pharmaeoeconomic impact of HOPE

The HOPE (Heart Outcomes and Prevention Evaluation) study has demonstrated a clear and beneficial effect of ramipril on cardiovascular events and dise ase progression. The cost-effectiveness of treatment with ramipril remains an important question that is being addressed by analysis of data from the main HOPE study and from a Swedish substudy. Data from the main HOPE study indicate that hospital costs per patient were reduced in the ramipril group compared with the placebo group. The net eff ect indicates that ramipril is cost neutral or could even be cost saving in US non-Medicare patients. In the Swedish health economic substudy, a separate protocol and separate c ase record forms were utilised to generate more specific data from the 537 Swedish patients faking part in HOPE. In this analysis, costs and effects a ssociated with each treatment group were assessed and incremental cost-effe ctiveness ratios were calculated The primary analysis was cost per life yea r gained which amounted to 29, 000 Swedish Kroner. In a world with a growing prevalence of cardiovascular disease and with add itional constraints on healthcare expenditure, analysis of the cost-effecti veness of preventive and curative medications is increasingly important. In this context, the early observations on the cost-effectiveness of ramipril appear very hopeful.