Lack of tyrosine protein kinase regulation of L-type Ca2+ channel current in transfected cells stably expressing alpha(1C-b) subunit

Authors
Sunagawa, M Nakamura, M Kosugi, T Hofmann, F Sperelakis, N
Citation
M. Sunagawa et al., Lack of tyrosine protein kinase regulation of L-type Ca2+ channel current in transfected cells stably expressing alpha(1C-b) subunit, JPN J PHYSL, 51(1), 2001, pp. 115-119
Citations number
9
Categorie Soggetti
Physiology
Journal title
JAPANESE JOURNAL OF PHYSIOLOGY
ISSN journal
0021521X → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
115 - 119
Database
ISI
SICI code
0021-521X(200102)51:1<115:LOTPKR>2.0.ZU;2-5
Abstract
Tyrosine protein kinase (Tyr-PK) regulation of L-type Ca2+ channel (Ca-L) c urrent was studied in COS-7 cells expressing vascular smooth muscle-type al pha (1C-b) with no auxiliary subunit by using a whole-cell voltage clamp. T he averaged peak amplitude of Cat currents was -0.33 +/-0.03 at holding pot ential of -60mV. Na3VO4 genistein and phosphorylated p60(c-src) peptide had no effect on the current. Thus the alpha (1C-b) subunif may not be involve d in Tyr-PK regulation of Ca-L current.