Synthesis of novel chiral quaternary phosphonium fluorides: reagents for simple asymmetric nucleophilic fluorination reactions

Authors
Beaumont, AJ Kiely, C Rooney, AD
Citation
Aj. Beaumont et al., Synthesis of novel chiral quaternary phosphonium fluorides: reagents for simple asymmetric nucleophilic fluorination reactions, J FLUORINE, 108(1), 2001, pp. 47-50
Citations number
10
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
108
Issue
1
Year of publication
2001
Pages
47 - 50
Database
ISI
SICI code
0022-1139(200103)108:1<47:SONCQP>2.0.ZU;2-4
Abstract
The novel chiral quaternary salt (R-P)-benzylmenthylmethylphenylphosphonium fluoride was synthesised. The compound was used in the asymmetric nucleoph ilic fluorination of 2-bromopropiophenone to give 7-fluoropropiophenone in a 35% yield with [alpha](D)(20) = +1.94 degrees. (C) 2001 Elsevier Science B.V. All rights reserved.