Enhancing release of peptide YY after near-total proctocolectomy: Jejunal pouch vs. ileal pouch-distal rectal anastomosis

Reconstructing the enteric tract after near-total proctocolectomy by interp osing a jejunal pouch between the distal ileum and the distal rectum slows small intestinal transit and decreases the number of stools per day compare d to a conventional ileal pouch-distal rectal reconstruction. Our hypothesi s was that the jejunal pouch operation brings about these results by protec ting the ability of the ileal mucosa to secrete peptide YY: thus augmenting the hormonal ileal brake on small intestinal transit and decreasing the st ool frequency. In five jejunal pouch dogs and five ileal pouch dogs, more t han G months after the operation, serum peptide YY concentrations were dete rmined before and at 30-minute intervals for 180 minutes after a standard m eal. Fasting serum concentrations of peptide T;ES measured by radioimmunoas say; were greater in jejunal pouch dogs (mean +/- SEM, 1340 +/- 143 pg/ml) than in ileal pouch dogs (804 +/- 52 pg/ml; P < 0.01). Postprandial peptide YY concentrations in jejunal pouch dogs were also greater at 30 minutes (j ejunal pouch = 1524 <plus/minus> 131 pg/ml, ileal pouch = 913 +/- 67 pg/ml; P = 0.01) and 60 minutes after the meal(jejunal pouch = 1723 +/- 250 pg/ml , ileal pouch = 1001 +/- 70 pg/ml; P = 0.05) and peaked sooner (jejunal pou ch = 81 +/- 17 minutes, ileal pouch = 147 +/- 12 minutes; P = 0.01). We con cluded that the jejunal pouch operation results in greater ileal fasting an d postprandial secretion of pel,tide YY than the ileal pouch operation. The greater release may account, in part, fur tile slower small bowel transit and decreased number of stools after the jejunal pouch operation.