We report here on three cases of mucinous ductal ectasia in which the
diagnosis was suggested by abdominal computed tomography and finally e
stablished by duodenoscopy with pancreatoscopy. Duodenoscopic examinat
ion of the ampulla of Vater demonstrated a patulous papillary orifice
and extrusion of viscid mucus. Pancreatoscopic examination was carried
out in all three patients, and characteristic findings such as papill
ary or villous mucosal projections coated with whitish gelatinous mucu
s were noted. In patients with mucinous ductal ectasia in whom the rad
iographic findings are equivocal, pancreatoscopic examination may prov
ide valuable information for the differential diagnosis of amorphous f
illing defects in the main pancreatic duct, and may provide informatio
n that helps to determine the extent of the pathology and the resectio
n margin.