Ultrasonography has been used in neurosurgical operative procedures for sev
eral decades. The authors report the case of a large pituitary tumor that w
as subtotally resected using endoscopy via the transnasal-transsphenoidal a
pproach, with the aid of transcranial real-time ultrasound. To our knowledg
e, this is the first reported case in which intraoperative transcranial-tra
nsdural real-time ultrasound was used to facilitate the resection of a skul
l base tumor.